The maximum allowed doses of carboplatin are: AUC 6 = 900 mg . Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand . FAQ. blood flow rate. . Carboplatin AUC Dose for Female calculator uses. (used for ideal body weight calculation):130 - 220 cm- Serum Alternatively, carboplatin may be dosed once weekly at an AUC of 1.5 IV for 12 weeks. Thus it is recommended to base 1 cycle of carboplatin dosing on the results of radioisotope renal scans or administer 2 cycles of therapy. AUC 4 = 600 mg . AUC = target area under the concentration versus time curve in mg/mLmin. Creatinine Clearance Calculator. Recalculation of carboplatin doses at each cycle is unnecessary, except when baseline kidney function (e.g., eGFR) alters by > 20% or when there is a change in the clinical status of the patient. 100 years old- Weight : 40 to120 kg - Height IBW calculation is performed with Lorentz Here is how the Carboplatin AUC Dose for Male calculation can be explained with given input values -> 6.000E+8 = 5* (95+25). AUC (Area Under the Curve) - the area under the pharmacokinetic curve - the concentration-time curve (change in the concentration of the active substance in plasma or serum over time). Repeat cycle every 3 weeks for 4 cycles with RT. ), carboplatin Dose (mg) = target AUC x (GFR + 25) is now the recommended formula. Height is necessary for weight correction in obese patients. Occasionally carboplatin is injected directly into a body cavity rather than the bloodstream. carboplatin Updated: September 2, 2022. Carboplatin AUC calculator; Calvert formula. min gave rise to manageable hematological toxicity in previously treated and untreated patients, respectively, and hence target AUC values of 5 and 7 mg/mL min are recommended for single-agent carboplatin in these patient groups. 1989 Nov;7(11):1748-56. link to original article contains verified formula PubMed NCCN Chemotherapy Order Templates Appendix B . Carboplatin AUC dose. CHATELUT formula Formula : Carboplatin dosage (mg) = AUC (mg/ml x min) x carboplatin clearance (ml/min) AUC = Area Under Curve OR. All Oncologists declared to use Calvert formula to calculate AUC 7 dose, and administered a median of 900 mg of carboplatin (range 690 to 1535). :- AUC = 3 to 8 mg/ml x min- Age : 18 to infusion over 60 minutes on Days 1, 8, and 15; Pembrolizumab 200 mg I.V. A carboplatin calculator is an instrument that measures the amount of carbon and platinum used in a catalytic converter. Kidney function was stable for all patients. Calculation steps for carboplatin d osage are available o n page 2 . Opioid Conversion Calculator. The chemotherapy only arm consisted of carboplatin (AUC 6) plus paclitaxel 175 mg/m 2 IV every 21 days for six cycles. How is the Calvert formula used to calculate AUC? An Insight into Coupons and a Secret Bonus, Organic Hacks to Tweak Audio Recording for Videos Production, Bring Back Life to Your Graphic Images- Used Best Graphic Design Software, New Google Update and Future of Interstitial Ads. To use this online calculator for Carboplatin AUC Dose for Male, enter Target AUC (AUC) & GFR for male (mL/min) (GFR) and hit the calculate button. Please note that dose is provided in mg not mg/m 2. Formula. (see Creatinine Clearance Calculation) Calvert AH, Newell DR, Gumbrell LA, et al. Carboplasm will be administered 1 hour prior to the gemcitabine infusion, bevacizumab will be administered 1 hour following chemotherapy infusion. Cisplatin + Etoposide 141,142,dd,mm-oo. The contents of this web page are protected. The formula is simplified in the equation as: d o s e = A U C ( [ 1.2 G F R] + 20). CHATELUT formula, Warning : You must verify result for dosage > 1g, Ranges & units GFR for Male = (((140-age) / serum creatinine) * 1) (weight (kg) / 72), GFR for Female = (((140-age) / serum creatinine) * 0.85) (weight (kg) / 72), Carboplatin Dose = Target AUC * (GFR + 25). Here is how the Carboplatin AUC Dose for Female calculation can be explained with given input values -> 5.850E+8 = 5*(92+25). What does the AUC stand for in chemotherapy? Other Medical Online Calculators The Oncology Lounge, Join the Doctors Lounge online medical community. Regardless of the number of cycles, the optimal dosing of carboplatin is calculated by the formula ( Calvert and Egorin, 2002 ). Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Body Surface Area Calculator. The dosage calculation based on CKD-EPI equation was largely similar to the latter. Maximum Infusion reactions to systemic chemotherapy reactions (of all types) with carboplatin is approximately 12 percent . creatinine : 53 to 531 ?mol/l, Related topics This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. This online calculator allows you to find the AUC of carboplatin for a patient using the Calvert formula. Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. Here is how the Carboplatin AUC Dose for Male calculation can be explained with given input values -> 6.000E+8 = 5*(95+25). Carboplatin dose is based on the Calvert formula: Dosage = Target AUC x (GFR* + 25) *Where the GFR is provided by the eCrCl. For a target AUC = 5, the maximum dose is 5 x 150 = 750 mg For a target AUC = 4, the maximum dose . Carboplatin is typically given once every 3-4 weeks (every 21-28 days), but may occasionally be given weekly (every 7 days). correction in obese patients. CALVERT FORMULA: Total Dose (mg) = (target AUC) x (GFR + 25); Note: With the Calvert formula, the total dose of carboplatin is calculated in mg, not mg/m2 Comments: This drug is usually administered by an infusion lasting 15 minutes or longer. In a sequential Phase II study, Carrato et al. Target AUC is the carboplatin target area under the concentration. This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. clearance for Female = (0,134xweight)+0.686x(218xweightx(1-0.00457xage)/serum cr?t.). Day 1: Carboplatin AUC 5-6 IV over 30 minutes. Intraperitoneal dosage Adults How to calculate Carboplatin AUC Dose for Female using this online calculator? MRN: Carboplatin Dose Calculator Updated: September 2, 2022: Calculation process . The area under the curve (AUC) of carboplatin was back-calculated from actual dosages using the Calvert formula. CALVERT FORMULA FOR CARBOPLATIN DOSING: Total Dose (mg) = (target AUC) x (GFR + 25) Calvert AH, Newell DR, Gumbrell LA, et al. CALVERT FORMULA FOR CARBOPLATIN DOSING: Total Dose (mg) = (target AUC) x (GFR + 25) Calvert AH, Newell DR, Gumbrell LA, et al. The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)]. The FDA has recommended that physicians consider capping the dose of carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. Please note that dose is provided in mg not mg/m 2. For any maths fans reading, here's the formula in full: Dose in milligrams = AUC x (A x GFR + B) 4 What does the AUC stand for in chemotherapy? Carboplatin dosage: prospective evaluation of a simple formula based on renal function. online articles. How to Calculate Carboplatin AUC Dose for Female? To use this online calculator for Carboplatin AUC Dose for Female, enter Target AUC (AUC) & GFR for female (mL/min) (GFR) and hit the calculate button. How often should carboplatin be administered? 6) Several factors must be considered in addition to the GFR to determine the precise dosage. AUC 5 = 750 mg . 16 studied a carboplatin AUC dose of 5 on Day 1 and a gemcitabine dose of 1000 mg/m 2 on Days 1, 8, and 15 in the 28-day regimen and on Days 1 and 8 in the 21-day regimen. Carboplatin dosage is calculated from sex, age, weight, serum creatinine and AUC (Area Under the Curve) of carboplatin. Dose (mg) = target AUC x (GFR + 25) is now the recommended formula. Blood flow rates vary from patient to patient, but most people require a blood flow rate of about 150 mL. Utilize the carboplatin dose calculator by the following method: Input: Select the gender Enter the age and weight of the patient Enter the serum creatinine level Enter the targeted AUC Hit the calculate button to find the dosage Output: The Calvert formula calculator displays the following result: Glomerular Filtration Rate (GFR) displayed Male = 50 kg + (2.3 * (Height in inches - 60)) Female = 45.5 kg + (2.3 * (Height in inches - 60)) Carboplatin dose based on the Calvert formula is: Dosage = Target AUC x (GFR + 25) Carboplatin and target AUC The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR. Evaluation of the Modified Diet in Renal Disease Equation for calculation of carboplatin dose. This is applicable to patients who receive hemodialysis within 12-18 h after . For obese patients : if total body weight(TBW)/ According to the median of calculated AUC, patients were divided into AUC 4 and <4 groups. 15 cycles All subjects will receive 15 mg/kg bevacizumab every 3 weeks cycle, 1000 mg/m of gemcitabine on day 1 and 8 every 3 weeks cycle and carboplatin (AUC= 5 ) every 3 weeks. Finally, select if you want mg or grams. Refer to regimen for target AUC. ideal body weight(IBW) >= 1.2, weight is corrected by the mean Dosage adjustments should be made according to the lowest post-treatment platelet or neutrophil value as assessed by weekly blood counts. The following issues are relevant to the carboplatin dose calculation: Total carboplatin dose is calculated in mg, not mg/m 2. 80 mg/m2 IV once weekly for 12 weeks in combination with carboplatin (AUC 5 IV on day 1 every 3 weeks for 4 cycles) and pembrolizumab (200 mg IV every 3 weeks OR 400 mg IV every 6 weeks); administer pembrolizumab prior to chemotherapy when given on the same day. A total of 79 patients had an AUC 4 and 72 patients had an AUC <4. The correlation between dose/AUC and GFR was high ( r = .851; two-sided P <.00001, t test). Calvert formula remains accurate when carboplatin is combined with etoposide, bleomycin, cisplatin, cyclophosphamide and ifosfamide; (5) some patients may experience more toxicity than others at equivalent AUC values; this may be due to the recovery capacity of the bone marrow in individual patients. During drug development, drug level sampling at multiple time points helps define the relationship between drug administration and the AUC. How to Market Your Business with Webinars? . Carboplatin dosage: prospective evaluation of a simple . The maximum dose is based on a GFR estimate that is capped at 125 mL/min for patients with normal renal function. Our carboplatin calculator computes the carboplatin dose in two steps: Calculating GFR using the Cockcroft-Gault equation: MEN: GFR = ( (140 - A) W / (72 Cr) WOMEN: GFR = 0.85 GFR formula for men where: `GRF`- Glomerular Filtration Rate `A` - age (years) `W` - weight (kg) `Cr` - serum creatinine (mg/dL) clearance for Male = (0,134xweight)+(218xweightx(1-0.00457xage)/serum creat. . Himanshi Sharma has verified this Calculator and 900+ more calculators! The. If two or more of the three patients experienced a Grade 3-4 AE during the first . In stage II, the authors used this formula to dose 31 patients for target AUCs of 3-8 mg/mL per minute. PEMEtrexed and CARBOplatin (AUC 5) Therapy Published: 22/11/2019 Review: 22/11/2021 Version number: 3 Tumour Group: Lung *,: : NCCP Chemotherapy Regimen This treatment is followed by adjuvant chemotherapy consisting of CARBOplatin at AUC 5 intravenously and 5-FU infusion at 1000 mg/m2/day by 96h infusion every 4 weeks for a total of three cycles, beginning 4 weeks after the end of radiation therapy. The oncologist specifies the dose for each patient individually. This formula has also been used in patients with end-stage renal disease on hemodialysis by assuming that the GFR is zero. Additional factors that should be assessed include: previous exposure to chemotherapy or radiotherapy, and overall health status. Reference NCCP Regimen 00261 CARBOplatin Monotherapy for information on calculation of CARBOplatin dose. 2 These methods are costly and require time and expertise. GFR for female (mL/min) describes the flow rate of filtered fluid through the kidney. CARBOplatin is administered once every 7 days concomitantly with radiotherapy for 6 cycles. Day 1: Carboplatin AUC 5 IV over 30 minutes. FAQ What is Carboplatin AUC Dose for Female? Biologically effective dose (BED) and equivalent dose (EQD2) calculators. A study by 10 patients in the control arm received carboplatin auc 5 on day 1, based on the calvert formula. J Clin Oncol. Kidney function should not be capped at 125 mL/min for use in the Calvert formula. The maximum dose is based on a GFR estimate that . The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)]. Carboplatin dose calculator: Other useful online medical calculators on Online Medical Calculators page. A clear relationship between carboplatin exposure, as quantified by area under the plasma concentration-time curve (AUC), and toxicity (thrombocytopenia) and response has been observed in ovarian cancer and other tumour types 9-11. The AUC can be computed by adjusting the values in the matrix so that cells where the positive case outranks the negative case receive a 1 , cells where the negative case has higher rank receive a 0 , and cells with ties get 0.5 (since applying the sign function to the difference in scores gives values of 1, -1, and 0 . This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. 1989;7:1748-1756. No pre- or post-treatment hydration or forced diuresis is required. ELIGIBILITY: Indications as above . infusion over 30 minutes on Day 1 . The maximum dose is based on a GFR estimate that is capped at 125 mL/min for patients with normal renal function. The 21-day regimen produced significantly less Grade 3/4 thrombocytopenia than the 28-day regimen, without any apparent . In routine oncologic practice, the carboplatin dosage is usually estimated based on AUC-based dosing since carboplatin clearance closely matches creatinine clearance. Carboplatin AUC Dose for Female calculator uses Carboplatin AUC Dose for Female (mg) = Target AUC*(GFR for female (mL/min)+25) to calculate the Carboplatin AUC Dose for Female (mg), Carboplatin AUC Dose for Female is used for calculating the dose based upon a patient's glomerular filtration rate and carboplatin target area under the concentration versus time curve. Carboplatin AUC 5 intravenous (I.V.) Carbo dose = target AUC (mg/ml/min) x (CrCl + 25) (ml/min) Please read the disclaimer before using this calculator. Accessed April 15, 2011. This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. This carboplatin dosing calculator uses the Calvert method to calculate the total carboplatin dose needed to achieve a given AUC (area under the free carboplatin plasma concentration versus time curve) while taking into account renal function. Carboplatin AUC Dose for Female is used for calculating the dose based upon a patient's glomerular filtration rate and carboplatin target area under the concentration versus time curve is calculated using, Carboplatin AUC Dose for Female Calculator. Days 1,8,15: Paclitaxel 80mg/m 2 IV over 1 hour, followed by: Day 1: Carboplatin AUC 5-6 IV over 30 minutes. Carboplatin dosage In the C-G equation to determine creatinine clearance, the adjusted body weight was used for BMI>or=27 patients and serum creatinine value of 70.7 microM (0.8 mg/dl) for the cachectic patients. Results: The median of AUC was 4 (1.8-5.5). 1989;7(11):1748-56; Memorial Sloan Kettering Cancer Center, New Guidelines for Carboplatin Dosing. AUC values of 4 to 6 and 6 to 8 mg/mL. The FDA has recommended that physicians consider capping the dose of carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. Carboplatin dosing. Therein lies the importance of measuring or estimating creatinine clearance. discuss challenging presentations with other members. Team Softusvista has created this Calculator and 600+ more calculators! Ann Pharmacother. J Clin Oncol. This is known as . For second line (crossover), carboplatin is administered AUC 5 IV every 21 days thereafter. AUC (Area Under the Curve) the area under the pharmacokinetic curve the concentration-time curve (change in the concentration of the active substance in plasma or serum over time). We use cookies to ensure that we give you the best experience on our website. The ratio of C02 to 02 is used as a carboplatin calculator. The lower this ratio, the more un-optimized your treatment is. min gave rise to manageable hematological toxicity in previously treated and untreated patients, respectively, and hence target AUC values of 5 and 7 mg/mL min are recommended for single-agent carboplatin in these patient groups. J Clin Oncol. The calvert formula is used to determine the dose of chemotherapy drugs such as 5-fluorouracil and carboplatin. J Clin Oncol. Here is how the Carboplatin AUC Dose for Female calculation can be explained with given input values -> 5.850E+8 = 5* (92+25). between TBW and IBW. Calvert AH, Newell DR, Gumbrell LA, et al. Would love your thoughts, please comment. The first step is to enter the total mg of platinum in your prescription. Brain tumor: 175 mg/m2 weekly for 4 weeks every 6 weeks, with a 2-week recovery period between courses. The Calvert formula has been extensively used to determine the dose of carboplatin for a fixed AUC and glomerular filtration rate (GFR). Carboplatin is a chemotherapy drug used to treat a number of cancers. 14 the auc calculation was based on gfr calculation according to the formula of jelliffe. infusion over 30 minutes on Day 1; Neoadjuvant Phase 1 is repeated every 3 weeks or 21 days. Editorial activities: Publish, peer review, edit Height is necessary for weight Carboplatin AUC Dose for Female (mg) is used for calculating the dose based upon a patient's glomerular filtration rate and carboplatin target area under the concentration versus time curve. 5 Which is more accurate, carboplatin GFR or AUC? May alternatively be given at AUC 1.5 on Days 1, 8, and 15; Paclitaxel 80 mg/m 2 I.V. This correction is calculated automatically by the Legal action may follow for reproduction of materials without permission. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. Following a dose of carboplatin, approximately 60-80% is excreted in the urine within the first 24 h 8, 9. Moderate (Carboplatin AUC < 5) Extravasation Potential: None The following table contains adverse effects reported with single agent carboplatin in the product monograph. After a bit more number crunching, they came up with what is now known as the Calvert formula - a calculation that's still used to this day to calculate the correct dose of carboplatin. To use this online calculator for Carboplatin AUC Dose for Male, enter Target AUC (AUC) & GFR for male (mL/min) (GFR) and hit the calculate button. The incidence is higher with repeated courses of therapy. Olaparib is a targeted therapy drug that is used for mCRPC and is approved by the FDA for this use. Carboplatin is a chemotherapy drug used to treat a number of cancers. In this phase, three patients were initially treated at full dose (carboplatin (AUC = 5) and avelumab 10 mg/kg). This is done by measuring the volume of air intake (V) and exhaust gases (E), which are then tabulated to provide the ratio between these gases. This can be due to larger tumors, higher tumor volumes, tumors located in blood vessels (which increases tumor blood flow), and poorly functioning platinum converting enzymes (which are encoded by a gene that produces the protein N-myc). program. For patients with recurrent ovarian cancer, administer single-agent carboplatin 360 mg/m2 IV (or AUC 5 to 6) on day 1, repeated every 4 weeks. Keeping the AUC within a defined range helps limit the dangerous side effects of chemotherapy. In this article, the development and application of a simple equation, known as the Calvert formula, are discussed. AUC is a quick measure of how much of the drug an individual has been exposed to in a given amount of time. 1989;7:1748-1756. The chemoradiation arm consisted of cisplatin 50 mg/m 2 IV days 1 and 29 with external beam radiation therapy, followed by carboplatin (AUC 5-6) plus paclitaxel 175 mg/m 2 IV every 21 days for four cycles. AUC = target area under the concentration versus time curve in mg/mLmin. The most relevant pharmacokinetic parameter for drug exposure is the area under the curve (AUC) of plasma concentration x time following a single dose. Which is more accurate, carboplatin GFR or AUC? If you continue to use this site we will assume that you are happy with it. Maximum Carboplatin Dose Calculation3 . 4 results. Please enter a valid weight. mg : References: 1. Carboplatin is a frequently used antitumour agent recommended to be administered according to the Calvert formula: dose = AUC x (GFR+25), where GFR is the glomerular filtration rate as measured by . Formula for calculation of IBW: Male = 50 kg + (2.3 kg x number of inches above 60 inches) Female = 45.5 kg + (2.3 kg x number of inches above 60 inches) For patients whose height is less than 60 inches, the estimation of ideal body weight or lean body weight are inconsistent at extremes of size using the current methods. However, . The total number of treatments recommended will vary based on your clinical circumstances, but an initial plan will be outlined for you by your doctor. Male = 50 kg + (2.3 x (Height in inches - 60)) Female = 45.5 kg + (2.3 x (Height in inches - 60)) The ideal weight result is converted in both kg and lbs for convenience, where (1 kg = 2.20462262 lbs). To use this online calculator for Carboplatin AUC Dose for Female, enter Target AUC (AUC) & GFR for female (mL/min) (GFR) and hit the calculate button. is calculated from sex, age, weight, serum creatinine and AUC (Area Under In this article, the development and application of a simple equation, known as the Calvert formula, are discussed. The higher this ratio, the better your catalytic converter is functioning. How is the carboplatin AUC and dosage calculated? The FDA has recommended that physicians consider capping the dose of carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. Carboplatin dose is based on the Calvert formula: Dosage = Target AUC x (GFR* + 25) *Where the GFR is provided by the eCrCl. patients in the experimental arm received gemcitabine 1,000 mg/m 2 on days 1 and 8 and carboplatin area under the curve (auc) 4 mg/ml/min on day 1. 1 A number of direct GFR measurements exist, such as the calculation on the basis of clearance of chromium-51 EDTA (51 Cr-EDTA). Carboplatin AUC Dose for Female (mg) is denoted by Carbo Dose symbol. The primary end . How to calculate Carboplatin AUC Dose for Female? Ask a Doctor Teams: Respond to patient questions and Days 1, 8: Cisplatin 50mg/m 2 IV over 60 minutes. FDA Center for Drug Evaluation and Research. Carboplatin dosing should not be based on estimated GFR. Glomerular Filtration Rated was estimated mainly by Cockroft-Gault formula (55% of pts), Jeliffe formula (27%), 24-hour urine collection (17%), MDRM (1%): median value was 106 ml/min (range 75 to 209). Carboplatin AUC Dose for Female is used for calculating the dose based upon a patient's glomerular filtration rate and carboplatin target area under the concentration versus time curve and is represented as. 5) AUC-based carboplatin dosing is more accurate than dosing according to BSA. the Curve) of carboplatin. Male = 50 kg + (2.3 x (Height in inches - 60)) Female = 45.5 kg + (2.3 x (Height in inches - 60)) The ideal weight result is converted in both kg and lbs for convenience, where (1 kg = 2.20462262 lbs). The model was reported to underpredict AUC by about 20% (1). Shord SS, Bressler LR, Radhakrishnan L, et al. AUC values of 4 to 6 and 6 to 8 mg/mL. Repeat cycle every 3 weeks for 6 cycles. Participants are prescribed olaparib which is taken orally at home, twice daily, 300 mg in 28 day cycles, as first line therapy. Based on the target carboplatin AUC, more than two thirds of patients were prescribed a carboplatin target AUC 5 mg/mL/min. The Latest Innovations That Are Driving The Vehicle Industry Forward. Formulas Used (Calculator will preform the necessary conversions): Calculation for carboplatin dose (Calvert Equation): Dose (mg) = Target AUC [(GFR +25)] Ideal Body Weight: 45.5 + [2.3 x (number of inches over 5ft tall)] for females Target AUC: mg/ml/min : 2022 - Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 The glomerular filtration rate (GFR), the fluid volume filtered from the capillaries of the renal glomeruli into the Bowman's capsule per unit time, is used for calculations of carboplatin chemotherapy doses. October 8, 2010. Carboplatin dose based on the Calvert formula is: Dosage = Target AUC x (GFR + 25) Carboplatin and target AUC The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR. The next step is entering the amount of oxygen and carbon dioxide in the patients exhaled breath. Ovarian cancer: 300-360 mg/m2 every 4 weeks or target AUC 5-7.5 every 3 weeks. eviQ calculators. 2009;43: . This online calculator allows you to find the AUC of carboplatin .